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By Sanjay Datta

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Types of Abnormalities Numerical Chromosomal Abnormalities In this group, the number of chromosomes is either more or less than 46. Down syndrome is the most common numerical chromosomal abnormality. Klinefelter syndrome (47, XXY) and Turner syndrome (46, X) are other examples. Trisomy 13 and trisomy 18 also have recognizable patterns of malformations; other autosomal trisomies are rarely seen in live births. Structural Chromosomal Abnormalities Here, a specific region on a particular chromosome is altered in some way.

A heart rate between 100 and 120 beats/min might either signify a compensated, mild hypoxic stress or be idiopathic and benign. When the heart rate falls below 60 beats/min, the fetus is in distress and requires either reversal of the cause of the bradycardia or emergency delivery. Other causes of bradycardia that are nonasphyxic in origin are bradyarrhythmias, maternal drug ingestion (especially beta blockers), and hypothermia. 8. Bradycardia, accompanied by absence of FHR variability. sionally seen with fetal asphyxia or with recovery from asphyxia, but is more likely seen secondary to these events: 1.

4. Reactive nonstress test, characterized by accelerations in the fetal heart rate (FHR) (top chart) with fetal movement (FM). 2. 5) 3. Uncertain reactivity: fewer than two fetal movements in 20 minutes or acceleration of less than 15 beats/min, longterm variability amplitude less than 10 beats/min, baseline heart rate outside of normal limits branes, multiple gestations, incompetent cervix, and women undergoing treatment for preterm labor). CSTs are interpreted as follows: 1. Negative: no late deceleration and normal baseline FHR Fetuses have sleep or inactive cycles that can last as long as 80 min.

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