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Download Advances in Topical Antifungal Therapy by R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.) PDF

By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

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As expected, the 628 cases of pityriasis versicolor required a treatment of just under 16 days, on average. Summarising this data for the individual diagnoses we arrive at a mean duration of treatment of just under 20 days. A comparison of the medians recorded in our study with the durations of treatment recommended for the individual indications indicates an astonishingly high degree of agreement. Differences in the duration of Table 2. 9 57 therapy between the patients treated with cream or solution were not found.

Our study was therefore aimed at determining whether bifonazole had any anti-inflammatory activity. In an uncontrolled observation study histamine was used to induce an allergic reaction in ten subjects pretreated for 2 h and for 2 and 12 h on 28 cm 2 skin with bifonazole, hydrocortisone and bifonazole basic cream and on an untreated control patch. Wheal and flare sizes were evaluated planimetrically after 15, 30, 60 and 90 min. In the histamine wheal test bifonazole and hydrocortisone showed an anti-inflammatory activity - in particular 15 and 30 min after triggering of the allergic reaction; wheal and flare surfaces were significantly smaller than the areas treated with the basic cream or left untreated.

Lalosevic 1, Rojas R, Astoroga E, Gip L (1984) Bifonazole cream in the treatment of superficial candidosis. Dermatologica 169 (suppll): 99 3. Lucker PW, Beubler E, Kukovetz WR, Ritter W (1984) Retention time and concentration in human skin of bifonazole and clotrimazole. Dermatologica 169 (suppl. 1): 51 4. Panconesi E, Di Fonzo E (1982) bifonazole in the treatment of superficial candidiasis and tinea pedis. In: Urabe H, Zaiss N, Stettendorf S (eds) International antifungal symposium on bifonazole.

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