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Extra info for Acute exposure guideline levels for selected airborne chemicals : volume 14.

Sample text

Effects observed at all exposures were reversed 7-days post-exposure with no medical intervention. Other human studies have uncertainties inherent in the exposure-route extrapolations that would be required if using human LC50 estimates (Ketchum 1963) or if using the non-verifiable LCt50 of 200,000 mg-min/m3 estimated by Hoenig (2007). Thus, animal studies were used as the basis for deriving AEGL3 values. AEGL-3 values for BZ were derived using 3,700 mg-min/m3 as the point of departure. S. Department of the Army 1974).

S. Department of the Army. 1974. Pp. 109-113 in Chemical Agent Data Sheets, Volume 1. Edgewood Arsenal Special Report AD 0030. S. Department of the Army, Edgewood Arsenal, Aberdeen Proving Ground, MD. Test species/Strain/Sex/Number: Monkeys; species, gender, and number not reported. Exposure route/Concentrations/Durations: Aerosol inhalation; LCt50 of 37,000 mg-min/m3 based on exposure durations of 6-25 min. Effects: LCt50 of 37,000 mg-min/m3 based on exposure durations of 6-25 min. End point/Concentration/Rationale: Lethality threshold estimated as one-tenth of LCt50; definitive information regarding the concentration-response relationship for BZ is lacking.

Environmental Protection Agency). The NAC reviewed and revised the document and AEGLs as deemed necessary. Both the document and the AEGL values were then reviewed by the National Research Council (NRC) Committee on Acute Exposure Guideline Levels. The NRC committee has concluded that the AEGLs developed in this document are scientifically valid conclusions based on the data reviewed by the NRC and are consistent with the NRC guidelines reports (NRC 1993, 2001). 13 14 Acute Exposure Guideline Levels effects.

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